Raven StealthCo - Principal Scientist, Analytical Chemistry

About Raven: We are Raven, RA Capital’s healthcare incubator. From discovery to delivery, whether we incubate, accelerate or rejuvenate, Raven’s goal is to turn scientific breakthroughs into transformative therapies and get them quickly, safely and efficiently to the patients that need them most. Raven’s experienced scientists, operators, and healthcare innovators have deep sector expertise across therapeutics, diagnostics, devices and services. They have brought hundreds of therapeutics into development, managed hospital systems, optimized clinical trials and navigated payor and regulatory systems to deliver patient impact - and they are ready to work with you. About RA Capital: Founded in 2004, RA Capital Management is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies. RA Capital creates and funds innovative companies, from private seed rounds to public follow-on financings, allowing management teams to drive value creation from inception through commercialization and beyond. RA Capital's knowledge engine is guided by our TechAtlas internal research division, and Raven, RA Capital’s company building team, offers entrepreneurs and innovators a collaborative and comprehensive platform to explore the novel and the re-imagined. RA Capital has more than 150 employees and over $10 billion in assets under management. Company Background We are a well-funded, stealth-mode biotechnology focused on next generation oligo-based modalities targeting tissues beyond the liver, muscle, and kidney. We are building a platform to deliver oligos with high precision to previously untargeted cells, while focused on “undruggable” genes, alone or in combination with previously validated targets. Many of our targets carry "pipeline-in-a-drug" potential: a single gene or protein with meaningful biological effects across multiple disease areas. Headquartered in Cambridge, Massachusetts, the company was incubated in RA Capital’s venture group (Raven) and is led by an experienced CEO. After a robust incubation and vetting process, Raven StealthCo was launched and funded by RA Capital. The company’s therapeutic areas of interest lie outside commonly targeted cells and tissues, and represent multi-billion-dollar markets that are continuing to grow as the population ages. Our initial focus is creating transformational therapies to treat diseases, but given the platform potential, we have longer-term ambitions to address healthy aging. These targets are backed by strong biological and genetic evidence but have historically resisted small molecule and biologic approaches. Raven StealthCo is moving quickly to address multiple disease indications at scale and with significant market potential. Opportunity We are in the discovery stage and will invest heavily in its emerging platform for oligonucleotide delivery. Our disease focus offers strong translatability from animal models to humans, which provides a potentially rapid and efficient path to the clinic. Given our recent funding and commitment to building a first-in-class platform with clear therapeutic targets and indications, we are recruiting a Principal Scientist, Analytical Chemistry. This individual will be responsible for developing analytical methods and characterizing our oligonucleotide conjugates for our targeted delivery platform. The Position The Principal Scientist, Analytical Chemistry will report directly to the Director of Oligonucleotide and Conjugation Chemistry and will interface frequently with members of the delivery group and cross-functional teams to advance oligonucleotide therapeutic programs. This individual will help define and execute the strategy to analyze oligonucleotides and conjugates in an efficient and timely manner. As a lab-based role, this person will assist in the implementation and use of scientific and analytical equipment to yield high-quality oligonucleotide and oligonucleotide-conjugate materials. Specific responsibilities for the Principal Scientist, Analytical Chemistry include: • Define and implement reproducible analytical protocols to characterize oligonucleotides for biological evaluation in our targeted delivery platform • Develop and implement QC methods to determine purity, composition, and concentration of oligonucleotides and conjugates using a toolbox of analytical methods (HPLC, MS, (bio)analytical assays, etc.) • Develop and implement analytical methods (e.g., MS) to determine drug-to-conjugate ratios of antibody-oligonucleotide conjugates • Develop and implement analytical methods to determine in vitro stability (e.g., serum stability) of oligonucleotides and conjugates • In conjunction with the biology group, assist in development and implementation of analytical methods to determine pharmacokinetics and distribution of oligonucleotides and conjugates in vivo • Assist in internal lab build, procuring and utilizing analytical equipment to characterize oligonucleotides and antibody/peptide-oligonucleotide conjugates • Assist conjugation scientists in developing methods (SEC, IEX, etc.) to purify oligonucleotide conjugates The Principal Scientist, Analytical Chemistry should be a doer with the ability to characterize high-quality conjugate materials efficiently and effectively, while contributing to the interpretation of complex scientific data. This person should have direct experience working on oligonucleotide platforms with a significant background in chemistry or a related discipline. This person must demonstrate strong technical skills, with a robust attention to detail to ensure rigorous and demonstrable results. Key qualifications for the Principal Scientist, Analytical Chemistry include: • PhD. in chemistry or related discipline with 6+ years of experience working with oligonucleotide therapeutics (siRNA, ASOs, etc.) in the biopharmaceutical industry; or BS/MS with 10+ years • Ideal candidate will have experience analyzing peptide-, protein-, or antibody-oligonucleotide conjugates, effectively operating in a cross-functional, collaborative environment • Adept in state-of-the-art analytical methods (SEC, IEX, RP-HPLC, MS, etc.) to characterize oligonucleotide conjugates • Experience in (bio)analytical assays to determine pharmacokinetic, distribution, and PD profiles of oligonucleotide therapeutics is a plus • While demonstrating creativity to contribute to the development of novel delivery systems, this individual must also be process- and detail-oriented to ensure proper release of high-quality oligonucleotide material for in vivo testing • Imperative that this individual be an effective communicator and proven team-player, with the ability to operate independently in a laboratory setting At a personal level, we are seeking an individual who is highly collaborative, intellectually curious, driven, trustworthy, humble, and who brings an adaptable and flexible working style. The Principal Scientist, Analytical Chemistry must be highly organized, thoughtful, and bring sound judgement and technical decision-making abilities. The company is creating a culture of highly engaged colleagues who put the team and the science above the self and operate with a sense of urgency. As such, the Principal Scientist, Analytical Chemistry should be highly nuanced in terms of their interpersonal style and able to lead and work effectively within a highly collaborative, entrepreneurial, and fast-paced start-up environment. From an educational perspective, we are seeking an individual with a Ph.D. and/or BS/MS in a relevant discipline such as chemistry or analytical sciences. It is understood that education, while an important index of achievement, orientation, and intellectual capacity, will not constitute the primary variable in this decision process. Personal characteristics, leadership abilities, technical fluency, creativity, work ethic, behavioral flexibility, and demonstrated accomplishments will serve as key components in the evaluation of candidates. This person will be based on-site at the company’s headquarters in Cambridge, MA. The base salary range reflects our good faith estimate at the time of posting. Final compensation will depend on factors like experience, skills, and location. The role may also be eligible for an annual bonus and long-term incentives. Compensation and benefits may be updated in the future. Salary base range $160,000—$190,000 USD